Here are clear, simple descriptions you can use:

Estrogen (E2 / Estradiol):
Estrogen is a hormone that plays a key role in sexual development, puberty, menstrual cycles, bone health, and overall growth. Estrogen testing helps evaluate hormonal balance and can be used to assess puberty development, menstrual irregularities, or certain medical conditions in all sexes.

Total Testosterone:
Total testosterone measures the overall amount of testosterone in the blood. Testosterone is important for growth, muscle and bone development, energy levels, and sexual development. This test is used to check hormone levels related to puberty, development, and hormonal health.